反应详情

The compound of Example 1G (36 mg) was dissolved in 0.3 mL of a solution of TsOH.H2O/CH2Cl2/THF (1.9 g/3 mL/3.8 mL); the resultant mixture was stirred at room temperature for 3 hour. The reaction mixture was added dropwise to NaHCO3 solution (2 mL, saturated) and then extracted with EtOAc (3×). The combined organic layer was washed with brine, dried over Na2SO4 and concentrated. The crude product was purified by preparative TLC to provide the titled compound (20 mg, 74% yield).

1. extractionextracted with EtOAc (3×)
2. washThe combined organic layer was washed with brine
3. dry with materialdried over Na2SO4
4. concentrationconcentrated
5. customThe crude product was purified by preparative TLC