反应详情

The compound of Example 1G (36 mg) was dissolved in 0.3 mL of a solution of TsOH.H2O/CH2Cl2/THF (1.9 g/3 mL/3.8 mL); the resultant mixture was stirred at room temperature for 3 hours. The reaction mixture was added dropwise to NaHCO3 solution (2 mL, saturated) and then extracted with EtOAc (3 times). The combined organic layer was washed with brine, dried over Na2SO4 and concentrated. The crude product was purified by preparative TLC to provide the title compound (20 mg, 74% yield).

1. extractionextracted with EtOAc (3 times)
2. washThe combined organic layer was washed with brine
3. dry with materialdried over Na2SO4
4. concentrationconcentrated
5. customThe crude product was purified by preparative TLC