反应详情

温度

150 °C

To methyl 2-(2-benzylpyrrolidin-1-yl)-5-chloronicotinate (D74) (75 mg, 0.226 mmol) in a mixture 1,4-dioxane/water (3 ml/1 ml), lithium hydroxide monohydrate (14.3 mg, 0.34 mmol) was added and the resulting mixture was stirred at 150° C. under microwave irradiation for 10 min (2 cycles of 5 min each). Solvents were evaporated in vacuo. The obtained residue was diluted with water/1M HCl (5 ml/15 ml) and extracted with ethyl acetate (3×30 ml). Collected fractions after solvent evaporation afforded the title compound (D100) (70 mg).

1. customSolvents were evaporated in vacuo
2. additionThe obtained residue was diluted with water/1M HCl (5 ml/15 ml)
3. extractionextracted with ethyl acetate (3×30 ml)
4. customCollected fractions after solvent evaporation