HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Hydroxymethyl)benzeneboronic acid → 2-Tert-butyl-5-(4-hydroxymethyl-phenyl)-1,1-dioxo-1,2-dihydro-1lambda6-isothiazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Hydroxymethyl)benzeneboronic acid | HCID 2734706 | — |
| Reactant | 2-Tert-butyl-5-chloro-2,3-dihydro-1lambda6,2-thiazole-1,1,3-trione | HCID 21878638 | — |
| Product | 2-Tert-butyl-5-(4-hydroxymethyl-phenyl)-1,1-dioxo-1,2-dihydro-1lambda6-isothiazol-3-one | HCID 58746547 | — |
Reaction Steps
This compound was prepared according to the procedure of Example 1.1, Step 4, using 9-A and 4-(hydroxymethyl)phenylboronic acid as the starting materials. 1H NMR (500 MHz, CDCl3): δ 7.77 (d, J=8.3 Hz, 2H), 7.52 (d, J=8.3 Hz, 2H), 6.64 (s, 1H), 4.79 (d, J=5.9 Hz, 2H), 1.86–1.84 (m, 1H), 1.73 (s, 9H); LCMS found for C14H17NO4SNa (M+Na)+: m/z=318.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07141596B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-5b45a7e2709249ffb94467e835e95b93 |
| Source note | uspto-grants-2006_11 |