1-Bromo-4-(methylsulphonyl)benzene → [4'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]methanol

HRID 724623Notes

Reaction equation

HRID 724623 reaction equation
CS([C:5]1[CH:6]=[C:7]([C:11]2[CH:16]=[CH:15][C:14]([CH2:17][OH:18])=[CH:13][CH:12]=2)[CH:8]=[CH:9][CH:10]=1)(=O)=O.BrC1C=C[C:23]([S:26](C)(=[O:28])=[O:27])=CC=1>>[CH3:23][S:26]([C:10]1[CH:5]=[CH:6][C:7]([C:11]2[CH:12]=[CH:13][C:14]([CH2:17][OH:18])=[CH:15][CH:16]=2)=[CH:8][CH:9]=1)(=[O:28])=[O:27]

Participants

3

Reactant 2

HCID 770141-Bromo-4-(methylsulphonyl)benzeneHCID 21879230(3'-Methanesulfonyl-biphenyl-4-yl)-methanol

Product 1

HCID 21878562[4'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]methanol

Procedure

This compound was prepared in a manner analogous to the preparation of (3′-methanesulfonyl-biphenyl-4-yl)-methanol (WO 01/70753, Example 27) using 1-bromo-4-methanesulfonyl-benzene as the starting material. LCMS found for C14H15O3S (M+H)+: m/z=263.

Sources & evidence

ORD record
ord-db3460dc0bf44c5492b0ac05b019275a
Source dataset
uspto-grants-2006_11
Patent number
US07141596B2

Reaction notes

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