反应详情

温度

70 °C

To a solution of methyl 5-chloro-2-(3-(3-fluorophenyl)-3-hydroxyazetidin-1-yl)nicotinate (D80) (70 mg, 0.207 mmol) in a mixture 3:1 1,4-dioxane/water (2 ml), lithium hydroxide monohydrate (133 mg, 0.312 mmol) was added and the resulting mixture was stirred 4 h at 70° C. After solvent evaporation the residue was taken in a mixture water/1M HCl (10 ml/10 ml) and extracted with ethylacetate (2×30 ml). Collected organics after solvent evaporation afforded the title compound (D111) (64.6 mg).

1. customAfter solvent evaporation the residue
2. extractionextracted with ethylacetate (2×30 ml)
3. customCollected organics after solvent evaporation