Trifluoroacetic acid → HCID 58746866, compound

HRID 724651Notes

Reaction equation

C([N:5]1[C:9](=[O:10])[CH2:8][CH:7]([C:11]2[CH:25]=[CH:24][C:14]([CH2:15][C:16]3([CH:22]=[O:23])[CH2:20][CH2:19][C:18](=[O:21])[NH:17]3)=[CH:13][CH:12]=2)[S:6]1(=[O:27])=[O:26])(C)(C)C.FC(F)(F)C(O)=O>>[O:27]=[S:6]1(=[O:26])[CH:7]([C:11]2[CH:25]=[CH:24][C:14]([CH2:15][C:16]3([CH:22]=[O:23])[CH2:20][CH2:19][C:18](=[O:21])[NH:17]3)=[CH:13][CH:12]=2)[CH2:8][C:9](=[O:10])[NH:5]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 58746799HCID 58746799, compound

Product 1

HCID 58746866HCID 58746866, compound

Conditions

Temperature: 130 °C

Procedure

2-[4-(2-tert-butyl-1,1-dioxido-3-oxoisothiazolidin-5-yl)benzyl]-5-oxopyrrolidine-2-carbaldehyde (4.5 mg, 0.011 mmol) was stirred in trifluoroacetic acid (1 mL, 10 mmol) in a small microwave tube and heated to 130° C. for 60 seconds. The mixture was evaporated and used directly. LCMS found for C15H17N2O5S (M+H)+: m/z=337.

Workup

customThe mixture was evaporated

Sources & evidence

ORD record: ord-20674ec97b1a414fa91025546f203e24
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07141596B2

Reaction notes

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