HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 724747Generated: October 30, 2026
3-Amino-1,2-propanediol → HCID 19598478, compound
https://huagongshe.com/reaction/724747
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Amino-1,2-propanediol | HCID 73561 | — |
| Reactant | 4,5,6,7-Tetrahydro-1-benzofuran-4-one | HCID 2733541 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 19598478 | HCID 19598478 | — |
Reaction Steps
9.4 g of 2,3-dihydroxypropylamine were added to a solution of 13.6 g of 4-oxo-4,5,6,7-tetrahydrobenzofuran in 200 cm3 of ethanol. The reaction medium was heated at 150° C. for 9 hours. After evaporation of the solvent and purification of the crude product on silica gel (ethyl acetate/methanol=9/1 ), 11.2 g of 4-oxo-4,5,6,7-tetrahydro-1-N-(β,γ-dihydroxypropyl)indole were recovered in the form of an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05704948 |
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| Source dataset | uspto-grants-1998_01 |
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| ORD ID | ord-64d0780c04eb4514831dc38e436d3772 |
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| Source note | uspto-grants-1998_01 |
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