Pyridine → HCID 9894232, compound

HRID 724810Notes

Reaction equation

[CH2:1]([NH:3][CH2:4][CH3:5])[CH3:2].Cl[CH2:7][CH2:8][O:9][C:10]([N:12]1[N:17]=[C:16]([C:18]2[CH:19]=[C:20]3[C:25](=[CH:26][CH:27]=2)[N:24]([C:28](=[O:39])[C:29]2[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[C:31]([O:37][CH3:38])[CH:30]=2)[CH2:23][CH2:22][CH2:21]3)[CH:15]([CH3:40])[S:14][C:13]1=[O:41])=[O:11].N1C=CC=CC=1>ClCCl>[CH2:1]([N:3]([CH2:7][CH2:8][O:9][C:10]([N:12]1[N:17]=[C:16]([C:18]2[CH:19]=[C:20]3[C:25](=[CH:26][CH:27]=2)[N:24]([C:28](=[O:39])[C:29]2[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[C:31]([O:37][CH3:38])[CH:30]=2)[CH2:23][CH2:22][CH2:21]3)[CH:15]([CH3:40])[S:14][C:13]1=[O:41])=[O:11])[CH2:4][CH3:5])[CH3:2]

Participants

Conditions

Temperature: 20 °C

Procedure

2.5 g of diethylamine dissolved in 30 ml of dichloromethane are added dropwise with stirring to a solution of 10 g of 3-[2-chloroethoxycarbonyl]-5-[1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzoyl)-6-quinolyl]-6-methyl-3,6-dihydro-2H-1,3,4-thiadiazin-2-one and 9 ml of pyridine in 100 ml of dichloromethane and the mixture is subsequently stirred at 20° C. for one hour. The solvent is removed and the mixture is worked up in the conventional manner to give 3-[2-(N,N-diethylamino)ethoxycarbonyl]-5-[1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzoyl)-6-quinolyl]-6-methyl-3,6-dihydro-2H-1,3,4-thiadiazin-2-one; hydrochloride.

Workup

additionare added dropwise
customThe solvent is removed

Sources & evidence

ORD record: ord-356a3a94de334aa5b9e8714c96f550f3
Source dataset: uspto-grants-1998_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05705497

Reaction notes

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