Hydrochloric Acid → HCID 178512489, compound

Participants

Reaction Steps

4.12 ml (39.12 mmol) of 3-chloro-aniline are placed in 25 ml of ethanol, and 3.3 g (78.4 mmol) of cyanamide are added. 5.3 ml (62.7 mmol) of concentrated hydrochloric acid are added dropwise to the brown solution. The reaction solution is then stirred for 20 hours at 78°. After concentration under reduced pressure, the residue is dissolved in 25 ml of water, and 6.3 g (78.4 mmol) of ammonium nitrate are added. The precipitated substance is isolated by filtration, washed with water and dried at 60° under HV. 3-chloro-phenyl-guanidine nitrate is obtained; 1H-NMR (dimethyl sulfoxide): 7.2-7.8 (7H,m), 9.9 (1H,br,s).

Provenance & Evidence