Hydrochloric Acid → HCID 178512489, compound

HRID 724814Notes

Reaction equation

HRID 724814 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[N:9]#[C:10][NH2:11].Cl.[N+:13]([O-:16])([O-:15])=[O:14].[NH4+]>C(O)C>[N+:13]([O-:16])([OH:15])=[O:14].[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][C:10]([NH2:11])=[NH:9])[CH:6]=[CH:7][CH:8]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 79323-ChloroanilineHCID 9864CyanamideHCID 22985Ammonium nitrate

Product 1

HCID 178512489HCID 178512489, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4.12 ml (39.12 mmol) of 3-chloro-aniline are placed in 25 ml of ethanol, and 3.3 g (78.4 mmol) of cyanamide are added. 5.3 ml (62.7 mmol) of concentrated hydrochloric acid are added dropwise to the brown solution. The reaction solution is then stirred for 20 hours at 78°. After concentration under reduced pressure, the residue is dissolved in 25 ml of water, and 6.3 g (78.4 mmol) of ammonium nitrate are added. The precipitated substance is isolated by filtration, washed with water and dried at 60° under HV. 3-chloro-phenyl-guanidine nitrate is obtained; 1H-NMR (dimethyl sulfoxide): 7.2-7.8 (7H,m), 9.9 (1H,br,s).

Workup

  1. concentrationAfter concentration under reduced pressure
  2. dissolutionthe residue is dissolved in 25 ml of water
  3. customThe precipitated substance is isolated by filtration
  4. washwashed with water
  5. customdried at 60° under HV

Sources & evidence

ORD record
ord-de92934535ab465dbac51bf2d9f2319b
Source dataset
uspto-grants-1998_01
Patent number
US05705502

Reaction notes

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