反应详情

15.1 g (0.0567 mmol) of 3-trifluoromethyl-phenyl-guanidine nitrate and 2.84 g (70.9 mmol) of sodium hydroxide are added to a suspension of 10 g (56.7 mmol) of 3-dimethylamino-1-(4-pyridyl)-2-propen-1-one [described in EP-A-0 233 461] in 300 ml of isopropanol The reaction mixture is boiled under reflux for 24 hours. After cooling, the product is isolated by filtration, washed with water and dried at 60° under HV. N-(3-trifluoromethyl-phenyl)-4-pyridyl-2-pyrimidineamine is obtained; m.p. 197°-198°, Rf =0.58 (ethyl acetate).

1. temperatureunder reflux for 24 hours
2. temperatureAfter cooling
3. customthe product is isolated by filtration
4. washwashed with water
5. customdried at 60° under HV