反应详情

10.57 g (33.4 mmol) of N-(3-trifluoromethyl-phenyl)-4-pyridyl-2-pyrimidineamine are suspended in 200 ml of methylene chloride, and 10.49 g (33.42 mmol, 55% strength) of m-chloroperbenzoic acid are added. After 2 hours, 200 ml of water are added. The reaction product is isolated by filtration, washed with sodium carbonate solution and water and, after drying, N-(3-trifluoromethyl-phenyl)-4-(N-oxido-4-pyridyl)-2-pyrimidineamine is obtained. More product is obtained by chromatography (methylene chloride:methanol=9: 1) of the concentrated mother liquor; Rf =0.16 (methylene chloride:methanol=9:1).

1. customThe reaction product is isolated by filtration
2. washwashed with sodium carbonate solution and water
3. customafter drying