反应详情

100 mg (0.293 mmol) of N-(3-trifluoromethyl-phenyl)-4-(2-cyano4-pyridyl)-2-pyrimidineamine are stirred in 15 ml of ethanol and 15 ml of 2N sodium hydroxide solution for 3 hours at 60°. After acidifying with 4N hydrochloric acid, N-(3-trifluoromethyl-phenyl)-4-(2-carboxy-4-pyridyl)-2-pyrimidineamine is obtained; m.p. 241°-245°, FAB-MS: 361 (M+ +H).