Bromine → HCID 10524413, compound

HRID 724933Notes

Reaction equation

HRID 724933 reaction equation
[Cl:1][C:2]1[C:7]([NH:8][C:9]([C:11]2[C:12]([NH:17][CH2:18][CH3:19])=[N:13][CH:14]=[CH:15][CH:16]=2)=[O:10])=[CH:6][CH:5]=[C:4]([Cl:20])[N:3]=1.C([O-])(=O)C.[K+].[Br:26]Br>C(O)(=O)C.O>[Cl:1][C:2]1[C:7]([NH:8][C:9]([C:11]2[C:12]([NH:17][CH2:18][CH3:19])=[N:13][CH:14]=[C:15]([Br:26])[CH:16]=2)=[O:10])=[CH:6][CH:5]=[C:4]([Cl:20])[N:3]=1

Participants

6

Reactant 3

HCID 24408BromineHCID 517044Potassium AcetateHCID 10828808N-(2,6-Dichloro-3-pyridinyl)-2-ethylamino-3-pyridinecarboxamide

Product 1

HCID 10524413HCID 10524413, compoundYield 91.4%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

To a solution of N-(2,6-dichloro-3-pyridinyl)-2-ethylamino-3-pyridinecarboxamide (7.4 g, 24 mmol) and potassium acetate (2.8 g, 28 mmol) in 90 mL of acetic acid was added bromine (1.2 mL, 23 mmol). After 15 min, the reaction mixture was diluted with water and the precipitate was collected by suction filtration to give 8.2 g of the title compound, suitable for use in the next reaction.

Workup

  1. filtrationthe precipitate was collected by suction filtration

Sources & evidence

ORD record
ord-6e0dd69969e54a58bc9d14da8ee9e638
Source dataset
uspto-grants-1998_01
Patent number
US05705499

Reaction notes

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