HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Vinylpyridine → HCID 470745, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Vinylpyridine | HCID 7502 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 8-Bromo-2-fluoro-5,11-dihydro-11-ethyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one | HCID 10807825 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Product | HCID 470745 | HCID 470745 | — |
Reaction Steps
8-Bromo-2-fluoro-5,11-dihydro-11-ethyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (70 mg, 0.2 mmol) was coupled with 4-vinylpyridine in the presence of bis(triphenylphosphine)palladium(II) chloride and (i-Pr)2NEt as described in example 1h. The product was hydrogenated as described in example 3b. Purification by flash chromatography (elution with methanol-dichloromethane) and recrystallization (diethyl ether-petroleum ether) afforded 26 mg of the title compound as white crystals, m.p. 109°-111° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05705499 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-9404a165a2a0483eb7228a1d85c1289d |
| Source note | uspto-grants-1998_01 |