反应详情

8-Bromo-2-fluoro-5,11-dihydro-11-ethyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (70 mg, 0.2 mmol) was coupled with 4-vinylpyridine in the presence of bis(triphenylphosphine)palladium(II) chloride and (i-Pr)2NEt as described in example 1h. The product was hydrogenated as described in example 3b. Purification by flash chromatography (elution with methanol-dichloromethane) and recrystallization (diethyl ether-petroleum ether) afforded 26 mg of the title compound as white crystals, m.p. 109°-111° C.

1. customas described in example 1h
2. customPurification
3. washby flash chromatography (elution with methanol-dichloromethane) and recrystallization (diethyl ether-petroleum ether)