HRID724942

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID137268

2-Ethynyl pyridine

C7H5N

HCID10547779

未命名化合物

PRODUCTS

生成物

结构：CCN1c2ncc(CCc3ccccn3)cc2C(=O)N(C)c2cccnc21

HCID470731

未命名化合物

HCID10665886

未命名化合物

PROCEDURE

实验过程

5,11-Dihydro-11-ethyl-5-methyl-8-(pyrid-2-yl)ethynyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (0.15 g) was prepared by coupling 5,11-dihydro-11-ethyl-8-iodo-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one with 2-ethynylpyridine by a procedure analogous to that described in Example 42a. Hydrogenation as described in Example 42b afforded 24 mg of the title compound, m.p. 70°-72° C. (ethyl acetate/hexanes).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bfcfba4d86d144cab648206187e7bfd3
来源数据集: uspto-grants-1998_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05705499
来源说明: uspto-grants-1998_01

反应 SMILES

[CH2:1]([N:3]1[C:9]2[N:10]=[CH:11][C:12](I)=[CH:13][C:8]=2[C:7](=[O:15])[N:6]([CH3:16])[C:5]2[CH:17]=[CH:18][CH:19]=[N:20][C:4]1=2)[CH3:2].[C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=1)#[CH:22]>>[CH2:1]([N:3]1[C:9]2[N:10]=[CH:11][C:12]([C:22]#[C:21][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=3)=[CH:13][C:8]=2[C:7](=[O:15])[N:6]([CH3:16])[C:5]2[CH:17]=[CH:18][CH:19]=[N:20][C:4]1=2)[CH3:2].[CH2:1]([N:3]1[C:9]2[N:10]=[CH:11][C:12]([CH2:22][CH2:21][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=3)=[CH:13][C:8]=2[C:7](=[O:15])[N:6]([CH3:16])[C:5]2[CH:17]=[CH:18][CH:19]=[N:20][C:4]1=2)[CH3:2]