Ethynylpyridine → 2-Ethyl-9-methyl-13-[2-(pyridin-2-yl)ethyl]-2,4,9,15-tetraazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-10-one

Participants

Reaction Steps

5,11-Dihydro-11-ethyl-5-methyl-8-(pyrid-2-yl)ethynyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (0.15 g) was prepared by coupling 5,11-dihydro-11-ethyl-8-iodo-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one with 2-ethynylpyridine by a procedure analogous to that described in Example 42a. Hydrogenation as described in Example 42b afforded 24 mg of the title compound, m.p. 70°-72° C. (ethyl acetate/hexanes).

Provenance & Evidence