HRID724948

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID139144

3-Hydroxyphenylacetylene

C8H6O

HCID10547779

未命名化合物

PRODUCTS

生成物

结构：CCN1c2ncc(CCc3cccc(O)c3)cc2C(=O)N(C)c2cccnc21

HCID15956323

未命名化合物

HCID19711136

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21584169

未命名化合物

PROCEDURE

实验过程

5,11-Dihydro-11-ethyl-5-methyl-8-(3-hydroxyphenyl)ethynyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (0.10 g) was prepared by coupling 5,11-dihydro-11-ethyl-8-iodo-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one with 3-hydroxyphenylacetylene by a procedure analogous to that described in Example 42a. Hydrogenation as described in Example 42b afforded 7 mg of the title compound, m.p. 177°-179° C. (ethyl acetate/ether).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-26f2bcfac740487aa27a0c3054b5b599
来源数据集: uspto-grants-1998_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05705499
来源说明: uspto-grants-1998_01

反应 SMILES

[CH2:1]([N:3]1[C:9]2[N:10]=[CH:11][C:12](I)=[CH:13][C:8]=2[C:7](=[O:15])[N:6]([CH3:16])[C:5]2[CH:17]=[CH:18][CH:19]=[N:20][C:4]1=2)[CH3:2].[OH:21][C:22]1[CH:23]=[C:24]([C:28]#[CH:29])[CH:25]=[CH:26][CH:27]=1>C(OCC)(=O)C.CCOCC>[CH2:1]([N:3]1[C:9]2[N:10]=[CH:11][C:12]([C:29]#[C:28][C:24]3[CH:25]=[CH:26][CH:27]=[C:22]([OH:21])[CH:23]=3)=[CH:13][C:8]=2[C:7](=[O:15])[N:6]([CH3:16])[C:5]2[CH:17]=[CH:18][CH:19]=[N:20][C:4]1=2)[CH3:2].[CH2:1]([N:3]1[C:9]2[N:10]=[CH:11][C:12]([CH2:29][CH2:28][C:24]3[CH:25]=[CH:26][CH:27]=[C:22]([OH:21])[CH:23]=3)=[CH:13][C:8]=2[C:7](=[O:15])[N:6]([CH3:16])[C:5]2[CH:17]=[CH:18][CH:19]=[N:20][C:4]1=2)[CH3:2]