HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Ethynylphenol → 5,11-Dihydro-11-ethyl-5-methyl-8-[2-(3-hydroxyphenyl)ethyl]-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Ethynylphenol | HCID 139144 | — |
| Reactant | HCID 10547779 | HCID 10547779 | — |
| Solvent | Diethylether ethylacetate | HCID 21584169 | — |
| Product | 5,11-Dihydro-11-ethyl-5-methyl-8-[2-(3-hydroxyphenyl)ethyl]-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one | HCID 15956323 | — |
| Product | 5,11-Dihydro-11-ethyl-5-methyl-8-(3-hydroxyphenyl)ethynyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one | HCID 19711136 | — |
Reaction Steps
5,11-Dihydro-11-ethyl-5-methyl-8-(3-hydroxyphenyl)ethynyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (0.10 g) was prepared by coupling 5,11-dihydro-11-ethyl-8-iodo-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one with 3-hydroxyphenylacetylene by a procedure analogous to that described in Example 42a. Hydrogenation as described in Example 42b afforded 7 mg of the title compound, m.p. 177°-179° C. (ethyl acetate/ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05705499 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-26f2bcfac740487aa27a0c3054b5b599 |
| Source note | uspto-grants-1998_01 |