4-Bromo-2-methylpyridine → HCID 19711129, compound

HRID 724954Notes

Reaction equation

HRID 724954 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH3:22])[C:7](=[O:21])[C:8]3[CH:18]=[C:17]([C:19]#[CH:20])[CH:16]=[N:15][C:9]=3[N:10]([CH2:13][CH3:14])[C:11]=2[N:12]=1.Br[C:24]1[CH:29]=[CH:28][N:27]=[C:26]([CH3:30])[CH:25]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH3:22])[C:7](=[O:21])[C:8]3[CH:18]=[C:17](/[CH:19]=[CH:20]/[C:24]4[CH:29]=[CH:28][N:27]=[C:26]([CH3:30])[CH:25]=4)[CH:16]=[N:15][C:9]=3[N:10]([CH2:13][CH3:14])[C:11]=2[N:12]=1

Participants

3

Reactant 2

HCID 27628354-Bromo-2-methylpyridineHCID 10567137HCID 10567137, compound

Product 1

HCID 19711129HCID 19711129, compoundYield 83.8%

Procedure

By a procedure analogous to that described in Example 51b, 48 mg (0.15 mmol) of 2-chloro-5,11-dihydro-11-ethyl-8-ethynyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one coupled with 4-bromo-2-picoline (31 mg, 0.15 mmol) to provide 51 mg (83%) of the title compound.

Sources & evidence

ORD record
ord-32dddd34aaf1465d99505ab150ddc7e5
Source dataset
uspto-grants-1998_01
Patent number
US05705499

Reaction notes

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