Catechol → HCID 470676, compound

HRID 724978Notes

Reaction equation

HRID 724978 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH3:22])[C:7](=[O:21])[C:8]3[CH:18]=[C:17]([CH2:19]Cl)[CH:16]=[N:15][C:9]=3[N:10]([CH2:13][CH3:14])[C:11]=2[N:12]=1.[C:23]1([C:25](=[CH:27][CH:28]=[CH:29][CH:30]=1)[OH:26])[OH:24]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH3:22])[C:7](=[O:21])[C:8]3[CH:18]=[C:17]([CH2:19][O:24][C:23]4[CH:30]=[CH:29][CH:28]=[CH:27][C:25]=4[OH:26])[CH:16]=[N:15][C:9]=3[N:10]([CH2:13][CH3:14])[C:11]=2[N:12]=1

Participants

3

Reactant 2

HCID 289CatecholHCID 108307382-chloro-8-chloromethyl-5,11-dihydro-11-ethyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

Product 1

HCID 470676HCID 470676, compoundYield 58%

Procedure

Using a procedure analogous to that described in Example 104, the title compound, m.p. 172°-173° C., was prepared from 2-chloro-8-chloromethyl-5,11-dihydro-11-ethyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one and catechol. The yield was 58% of theory.

Sources & evidence

ORD record
ord-dcd2c6037c4149d697420094f151b10b
Source dataset
uspto-grants-1998_01
Patent number
US05705499

Reaction notes

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