Hydrochloric Acid → HCID 67653830, compound

HRID 725119Notes

Reaction equation

HRID 725119 reaction equation
[CH2:1]([O:8][C:9]1[CH:31]=[CH:30][C:29]([O:32][CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[CH:28][C:10]=1[C:11]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][C:25]([OH:27])=[O:26])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH2:41](O)[CH3:42]>>[CH2:1]([O:8][C:9]1[CH:31]=[CH:30][C:29]([O:32][CH2:33][C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)=[CH:28][C:10]=1[C:11]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][C:25]([O:27][CH2:41][CH3:42])=[O:26])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 67654344HCID 67654344, compound

Product 1

HCID 67653830HCID 67653830, compoundYield 64%

Procedure

To a solution of 4 g (7.5 mmol) of 12-{N-[2,5-di(benzyloxy)benzoyl]amino}dodecanoic acid (compound of Example 6) in 23 ml of anhydrous ethanol, 7.5 mmol of 20% ethanolic hydrogen chloride solution were added and the reaction mixture was stirred for 4.5 hours. After cooling the precipitate was filtered, washed with ether and dried to give 2.69 g (64%) of the aimed compound, m.p.: 70°-71° C.

Workup

  1. temperatureAfter cooling the precipitate
  2. filtrationwas filtered
  3. washwashed with ether
  4. customdried

Sources & evidence

ORD record
ord-f38a25be79a947cda1ae63ea6b4d78ae
Source dataset
uspto-grants-1998_01
Patent number
US05705529

Reaction notes

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