Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → HCID 67958579, compound

HRID 72520Notes

Reaction equation

HRID 72520 reaction equation
[F:1][C:2]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9]2[N:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:10]=2[C:11]([OH:13])=O)[CH2:6]1.Cl.[NH2:28][C:29]1([C:32]2[CH:41]=[CH:40][C:35]([C:36]([O:38][CH3:39])=[O:37])=[CH:34][CH:33]=2)[CH2:31][CH2:30]1>>[F:1][C:2]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:3]=1[O:4][CH:5]1[CH2:6][N:7]([C:9]2[N:17]=[CH:16][C:15]([C:18]([F:19])([F:21])[F:20])=[CH:14][C:10]=2[C:11]([NH:28][C:29]2([C:32]3[CH:41]=[CH:40][C:35]([C:36]([O:38][CH3:39])=[O:37])=[CH:34][CH:33]=3)[CH2:31][CH2:30]2)=[O:13])[CH2:8]1

Participants

3

Reactant 2

HCID 66824369Methyl 4-(1-aminocyclopropyl)benzoate hydrochlorideHCID 679584342-(3-(2,4-Difluorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid

Product 1

HCID 67958579HCID 67958579, compoundYield 76.5%

Procedure

The title compound (D178) (106 mg) was prepared according to the experimental procedure described in Description 144 starting from 2-(3-(2,4-difluorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid (D127) (95 mg, 0.253 mmol) and methyl 4-(1-aminocyclopropyl)benzoate (D7) (57.79 mg, 0.253 mmol).

Sources & evidence

ORD record
ord-49b916ba6c0140f5a2f13ab29a848085
Source dataset
uspto-grants-2014_09
Patent number
US08828987B2

Reaction notes

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