Sodium Cyanide → 4-Amino-1-methylpiperidine-4-carbonitrile

HRID 725216Notes

Reaction equation

HRID 725216 reaction equation
[OH-].[NH4+:2].[Cl-].[NH4+:4].[C-:5]#N.[Na+].[CH3:8][N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=O>>[NH2:2][C:12]1([C:5]#[N:4])[CH2:13][CH2:14][N:9]([CH3:8])[CH2:10][CH2:11]1

Participants

5

Reactant 4

HCID 8929Sodium CyanideHCID 13603N-Methyl-2-piperidoneHCID 14923Ammonium HydroxideHCID 25517Ammonium Chloride

Product 1

HCID 114349914-Amino-1-methylpiperidine-4-carbonitrile

Procedure

Using the procedure of Stage 1 of Example 1, 8 ml of ammonium hydroxide, 1.58 g of ammonium chloride and 1.23 g of sodium cyanide were reacted and 2.5 ml of 1-methylpiperidone were added. The mixture was stirred for 18 hours at ambient temperature, followed by extraction 3 times with chloroform. The organic phase was washed with salt water and dried to obtain 2.41 g of the expected product (orange-yellow syrup).

Workup

  1. customwere reacted
  2. extractionfollowed by extraction 3 times with chloroform
  3. washThe organic phase was washed with salt water
  4. customdried

Sources & evidence

ORD record
ord-69b0063f20e64da6a6d789c9105289d4
Source dataset
uspto-grants-1998_01
Patent number
US05705654

Reaction notes

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