Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → HCID 67958218, compound

HRID 72522Notes

Reaction equation

HRID 72522 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([O:7][CH:8]2[CH2:11][N:10]([C:12]3[N:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][C:13]=3[C:14](O)=[O:15])[CH2:9]2)[CH:3]=1.Cl.[NH2:26][C:27]1([C:30]2[CH:39]=[CH:38][C:33]([C:34]([O:36][CH3:37])=[O:35])=[CH:32][CH:31]=2)[CH2:29][CH2:28]1>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([O:7][CH:8]2[CH2:11][N:10]([C:12]3[N:20]=[CH:19][C:18]([C:21]([F:23])([F:24])[F:22])=[CH:17][C:13]=3[C:14]([NH:26][C:27]3([C:30]4[CH:39]=[CH:38][C:33]([C:34]([O:36][CH3:37])=[O:35])=[CH:32][CH:31]=4)[CH2:29][CH2:28]3)=[O:15])[CH2:9]2)[CH:3]=1

Participants

3

Reactant 2

HCID 66824369Methyl 4-(1-aminocyclopropyl)benzoate hydrochlorideHCID 679586352-(3-((5-Methylisoxazol-3-yl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid

Product 1

HCID 67958218HCID 67958218, compoundYield 70.4%

Procedure

The title compound (D180) (20 mg) was prepared according to the experimental procedure described in Description 144 starting from 2-(3-((5-methylisoxazol-3-yl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid (D129) (19 mg, 0.055 mmol) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (D7) (12.6 mg, 0.055 mmol).

Sources & evidence

ORD record
ord-e80b043fa4534593be42bae7a2e9b04c
Source dataset
uspto-grants-2014_09
Patent number
US08828987B2

Reaction notes

Loading…