HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → Methyl 4-(1-(5-(trifluoromethyl)-2-(3-((6-(trifluoromethyl) pyridin-2-yl)oxy)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride | HCID 66824369 | — |
| Reactant | 5-(Trifluoromethyl)-2-(3-((6-(trifluoromethyl)pyridin-2-yl)oxy)azetidin-1-yl)nicotinic acid | HCID 86697877 | — |
| Product | Methyl 4-(1-(5-(trifluoromethyl)-2-(3-((6-(trifluoromethyl) pyridin-2-yl)oxy)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate | HCID 86697881 | 68.4% |
Reaction Steps
The title compound (D181) (75 mg) was prepared according to the experimental procedure described in Description 144 starting from 5-(trifluoromethyl)-2-(3-((6-(trifluoromethyl)pyridin-2-yl)oxy)azetidin-1-yl)nicotinic acid (D130) (77 mg, 0.189 mmol) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (D7) (43.04 mg, 0.189 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828987B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-b1cc043b5ca74ef0b57e42026d14aeb7 |
| Source note | uspto-grants-2014_09 |