HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → Methyl 4-(1-(2-(3-(3-chlorophenoxy)azetidin-1-yl)-5-fluoronicotinamido)cyclopropyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride | HCID 66824369 | — |
| Reactant | 2-(3-(3-Chlorophenoxy)azetidin-1-yl)-5-fluoronicotinic acid | HCID 67958151 | — |
| Product | Methyl 4-(1-(2-(3-(3-chlorophenoxy)azetidin-1-yl)-5-fluoronicotinamido)cyclopropyl)benzoate | HCID 67966658 | 56.3% |
Reaction Steps
The title compound (D188) (12 mg) was prepared according to the experimental procedure described in Description 169 starting from 2-(3-(3-chlorophenoxy)azetidin-1-yl)-5-fluoronicotinic acid (D133) (14 mg, 0.043 mmol) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (D7) (9.85 mg, 0.043 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828987B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-c91fa6d648554ee789238ca7d88f7e08 |
| Source note | uspto-grants-2014_09 |