HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → methyl 4-((1S)-1-(5-chloro-2-(3-(4-fluorophenoxy)pyrrolidin-1-yl)nicotinamido)ethyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride | HCID 57462942 | — |
| Reactant | 5-Chloro-2-(3-(4-fluorophenoxy)pyrrolidin-1-yl)nicotinic acid | HCID 67958506 | — |
| Product | methyl 4-((1S)-1-(5-chloro-2-(3-(4-fluorophenoxy)pyrrolidin-1-yl)nicotinamido)ethyl)benzoate | HCID 67958668 | 40.2% |
Reaction Steps
The title compound (D193) (64 mg) was prepared according to the experimental procedure described in Description 146 starting from 5-chloro-2-(3-(4-fluorophenoxy)pyrrolidin-1-yl)nicotinic acid (D138) (110 mg, 0.320 mmol), and (S)-methyl 4-(1-aminoethyl)benzoate (D3) (68.82 mg, 0.320 mmol) MS: (ES/+) m/z: 499.2 [MH+] C26H25ClFN3O4 requires 497.15
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828987B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-dd7684be12774ab6b9f2d3e32af4ef33 |
| Source note | uspto-grants-2014_09 |