Sulfuric Acid → alpha-(3,4-Dimethoxy-5-nitrophenyl)-2-thiophenemethanol

HRID 725430Notes

Reaction equation

HRID 725430 reaction equation
C([Li])CCC.[S:6]1[CH:10]=[CH:9][CH:8]=[CH:7]1.[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[C:19]([N+:23]([O-:25])=[O:24])[C:20]=1[O:21][CH3:22])[CH:16]=[O:17].S(=O)(=O)(O)O>O1CCCC1>[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:16]([C:7]2[S:6][CH:10]=[CH:9][CH:8]=2)[OH:17])[CH:18]=[C:19]([N+:23]([O-:25])=[O:24])[C:20]=1[O:21][CH3:22]

Participants

6

Reactant 4

HCID 1118Sulfuric AcidHCID 8030ThiopheneHCID 108675653,4-Dimethoxy-5-nitrobenzaldehydeHCID 178418339Butyllithium

Product 1

HCID 21458951alpha-(3,4-Dimethoxy-5-nitrophenyl)-2-thiophenemethanol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

18.8 ml of n-butyllithium solution (1.6M in hexane) are added dropwise at -50° within 10 minutes to 4.03 g of thiophene dissolved in 40 ml of tetrahydrofuran. After stirring at -50° for 30 minutes 6.3 g of 3,4-dimethoxy-5-nitrobenzaldehyde dissolved in 100 ml of tetrahydrofuran are added dropwise within 30 minutes. The reaction mixture is stirred at -50° for 1 hour at 0° for 30 minutes and poured into 100 ml of 2N sulphuric acid. The mixture is extracted three times with 100 ml of ether each time; the combined ether phases are washed with sodium chloride solution, dried over sodium sulfate, filtered and evaporated. There is obtained α-(3,4-dimethoxy-5-nitrophenyl)-2-thiophenemethanol of m.p. 79°-81° (from methylene chloride/hexane).

Workup

  1. additionare added dropwise within 30 minutes
  2. extractionThe mixture is extracted three times with 100 ml of ether each time
  3. washthe combined ether phases are washed with sodium chloride solution
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. customevaporated

Sources & evidence

ORD record
ord-1fa758aa38dc4f688bbfe8baec16520b
Source dataset
uspto-grants-1998_01
Patent number
US05705703

Reaction notes

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