反应详情

温度

70 °C

To a solution of methyl 6-((5-chloro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinamido)methyl)nicotinate (D159) (22 mg, 0.045 mmol) in a mixture 1-4dioxane/water (1.5 ml/0.5 ml), lithium hydroxide hydrate (2.8 mg, 0.067 mmol) was added. The reaction mixture was heated to 70° C. for 1 h. After solvent evaporation the residue was taken in water (10 ml) and 1M HCl (10 ml) and extracted with ethylacetate (2×20 ml). Collected aorganics after solvent evaporation afforded the title compound (E24) (19 mg)

1. customAfter solvent evaporation the residue
2. extraction1M HCl (10 ml) and extracted with ethylacetate (2×20 ml)
3. customCollected aorganics after solvent evaporation