反应详情

温度

70 °C

To a solution of methyl 6-((5-chloro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinamido)methyl)nicotinate (D160) (40.5 mg, 0.079 mmol) in a mixture 1-4 dioxane/water (1.5 ml/0.5 ml), lithium hydroxide hydrate (10 mg, 0.24 mmol) was added. The reaction mixture was heated to 70° C. under microwave irradiation for 20 min (4 cycles of 5 min each). After solvent evaporation the residue was taken in water (5 ml) and 1M HCl (5 ml) and extracted with ethylacetate (3×10 ml). Collected organics after solvent evaporation afforded the title compound (E25) (29 mg)

1. customAfter solvent evaporation the residue
2. extraction1M HCl (5 ml) and extracted with ethylacetate (3×10 ml)
3. customCollected organics after solvent evaporation