反应详情

4-(1-(5-chloro-2-(3-(3-fluorobenzoyl)azetidin-1-yl)nicotinamido)cyclopropyl)benzoic acid (E25) (12.6 mg, 0.025 mmol) was dissolved in dry pyridine (1.2 ml) then O-methylhydroxylamine hydrochloride (4.3 mg, 0.051 mmol) was added and the resulting mixture was stirred at room temperature for 60 h. Solvents were evaporated in vacuo, and the residue was diluted with water (5 ml) and extracted with ethylacetate (3×20 ml). Collected organics, after solvent evaporation, afforded a residue that was washed with methanol and dried in vacuo to afford the title compound (E26) (D021/092/2) (3 mg).

1. customSolvents were evaporated in vacuo
2. additionthe residue was diluted with water (5 ml)
3. extractionextracted with ethylacetate (3×20 ml)
4. customCollected organics, after solvent evaporation
5. customafforded a residue that
6. washwas washed with methanol
7. customdried in vacuo