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HRID725641

反应详情

EQUATION

反应方程式

HRID 725641 的结构方程式

REACTANTS

反应物

2
结构：C[Si](C)(C)Br
HCID76113

Silane, bromotrimethyl-

C3H9BrSi

结构：COCCCOc1cc(CO)ccc1OC
HCID45108163

[4-Methoxy-3-(3-methoxypropoxy)phenyl]methanol

C12H18O4

PRODUCTS

生成物

1
结构：COCCCOc1cc(CBr)ccc1OC
HCID11558329

4-(Bromomethyl)-1-methoxy-2-(3-methoxypropoxy)benzene

C12H17BrO3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClC(Cl)Cl
溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

97 ml of trimethylbromosilane are added, with stirring at room temperature, to 113.1 g of 4-methoxy-3-(3-methoxypropyloxy)-benzyl alcohol in 1.31 liters of chloroform. After 10 minutes the solvent is evaporated off and the residue is immediately purified by means of FC (900 g of silica gel, eluant: ethyl acetate/hexane 1:3). The title compound is obtained: Rf (ethyl acetate/hexane=1:2)=0.34; m.p. 50°-51° C.

WORKUP

后处理

  1. customAfter 10 minutes the solvent is evaporated off
  2. customthe residue is immediately purified by means of FC (900 g of silica gel, eluant: ethyl acetate/hexane 1:3)