HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromotrimethylsilane → 4-(Bromomethyl)-1-methoxy-2-(3-methoxypropoxy)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromotrimethylsilane | HCID 76113 | — |
| Reactant | 4-Methoxy-3-(3-methoxypropoxy)benzenemethanol | HCID 45108163 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4-(Bromomethyl)-1-methoxy-2-(3-methoxypropoxy)benzene | HCID 11558329 | — |
Reaction Steps
97 ml of trimethylbromosilane are added, with stirring at room temperature, to 113.1 g of 4-methoxy-3-(3-methoxypropyloxy)-benzyl alcohol in 1.31 liters of chloroform. After 10 minutes the solvent is evaporated off and the residue is immediately purified by means of FC (900 g of silica gel, eluant: ethyl acetate/hexane 1:3). The title compound is obtained: Rf (ethyl acetate/hexane=1:2)=0.34; m.p. 50°-51° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05705658 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-14a306f66d2b4b0e9688f840a401cf20 |
| Source note | uspto-grants-1998_01 |