Aminoacetaldehyde dimethyl acetal → HCID 19708584, compound

HRID 725762Notes

Reaction equation

HRID 725762 reaction equation
[Cl:1][C:2]1[C:3](OS(O)(=O)=O)=[C:4]2[C:9](=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=1)[NH:8][C:7](=[O:16])[C:6]([C:17](=[O:21])[CH:18]([CH3:20])[CH3:19])=[C:5]2C.[CH3:28][O:29][CH:30]([O:33][CH3:34])[CH2:31][NH2:32]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=1)[NH:8][C:7](=[O:16])[C:6]([C:17](=[O:21])[CH:18]([CH3:19])[CH3:20])=[C:5]2[NH:32][CH2:31][CH:30]([O:33][CH3:34])[O:29][CH3:28]

Participants

3

Reactant 2

HCID 89728Aminoacetaldehyde dimethyl acetalHCID 86751877HCID 86751877, compound

Product 1

HCID 19708584HCID 19708584, compoundYield 73%

Procedure

6-Chloro-3-isobutyryl-4-methylsulfoxy-8-trifluoromethyl-2-quinolinone (379 mg, 1 mmol) and 2,2-dimethoxyethylamine (105 mg, 1 mmol) were used and the reaction was carried out as in the above process of example 1 to obtain the desired product (307 mg, yield: 73%).

Sources & evidence

ORD record
ord-14a2b80461a8459fa66ea3a155804564
Source dataset
uspto-grants-1998_01
Patent number
US05707931

Reaction notes

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