Propargylamine → HCID 19708585, compound

HRID 725763Notes

Reaction equation

[Cl:1][C:2]1[C:3](OS(O)(=O)=O)=[C:4]2[C:9](=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=1)[NH:8][C:7](=[O:16])[C:6]([C:17]([CH:19]1[CH2:21][CH2:20]1)=[O:18])=[C:5]2C.[CH2:28]([NH2:31])[C:29]#[CH:30]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]([F:13])([F:14])[F:15])[CH:11]=1)[NH:8][C:7](=[O:16])[C:6]([C:17]([CH:19]1[CH2:20][CH2:21]1)=[O:18])=[C:5]2[NH:31][CH2:28][C:29]#[CH:30]

Participants

Reactant 2

HCID 239041Propargylamine

HCID 131720380HCID 131720380, compound

Product 1

HCID 19708585HCID 19708585, compoundYield 72%

Procedure

6-Chloro-3-cyclopropanecarbonyl-4-methylsulfoxy-8-trifluormethyl-2-quinolinone (377 mg, 1 mmol) and propargylamine (55 mg, 1 mmol) were used and the reaction was carried out as in the above process of example 1 to obtain the desired product (265 mg, yield: 72%).

Sources & evidence

ORD record: ord-350511b63e154308b663f91e5a54d452
Source dataset: uspto-grants-1998_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05707931

Reaction notes

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