Propargylamine → HCID 19708599, compound

HRID 725764Notes

Reaction equation

[C:1]([C:4]1[C:5](=[O:25])[NH:6][C:7]2[C:12]([C:13]=1C)=[C:11](OS(O)(=O)=O)[C:10]([Cl:20])=[CH:9][C:8]=2[C:21]([F:24])([F:23])[F:22])(=[O:3])[CH3:2].[CH2:26]([NH2:29])[C:27]#[CH:28]>>[C:1]([C:4]1[C:5](=[O:25])[NH:6][C:7]2[C:12]([C:13]=1[NH:29][CH2:26][C:27]#[CH:28])=[CH:11][C:10]([Cl:20])=[CH:9][C:8]=2[C:21]([F:24])([F:23])[F:22])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 239041Propargylamine

HCID 86748764HCID 86748764, compound

Product 1

HCID 19708599HCID 19708599, compoundYield 83%

Procedure

3-Acetyl-6-chloro-4-methylsulfoxy-8-trifluoromethyl-2-quinolinone (351 mg, 1 mmol) and propargylamine (55 mg, 1 mmol) were used and the reaction was carried out as in the above process of example 1 to obtain the desired product (284 mg, yield: 83%).

Sources & evidence

ORD record: ord-f5435d81e5b24f0a96ddc6a9695b8ac7
Source dataset: uspto-grants-1998_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05707931

Reaction notes

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