Propargylamine → HCID 19708602, compound

HRID 725766Notes

Reaction equation

[Cl:1][C:2]1[C:3](OS(O)(=O)=O)=[C:4]2[C:9](=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=1)[NH:8][C:7](=[O:16])[C:6]([C:17](=[O:20])[CH2:18][CH3:19])=[C:5]2C.[CH2:27]([NH2:30])[C:28]#[CH:29]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]([F:14])([F:15])[F:13])[CH:11]=1)[NH:8][C:7](=[O:16])[C:6]([C:17](=[O:20])[CH2:18][CH3:19])=[C:5]2[NH:30][CH2:27][C:28]#[CH:29]

Participants

Reactant 2

HCID 239041Propargylamine

HCID 86751878HCID 86751878, compound

Product 1

HCID 19708602HCID 19708602, compoundYield 87%

Procedure

6-Chloro-4-methylsulfoxy-3-propionyl-8-trifluoromethyl-2-quinolinone (365 mg, 1 mmol) and propargylamine (55 mg, 1 mmol) were used and the reaction was carried out as in the above process of example 1 to obtain the desired product (310 mg, yield: 87%).

Sources & evidence

ORD record: ord-10fa0977caf349398056c8d62c7a8f14
Source dataset: uspto-grants-1998_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05707931

Reaction notes

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