反应详情

Hydrogen bromide was passed at -5° C. into a solution of 14.8 g of methyl α-[2-(2-methylphenyloxymethyl)phenyl]but-2-enoate in 250 ml of methylene chloride until it was saturated (about 18 g of HBr). After termination of the reaction (about 2 h at 25° C.), the solvent was distilled off under reduced pressure. The residue thus obtained was taken up in 300 ml of cyclohexane. The solution was washed with 5% strength sodium hydroxide solution and then with water. After drying and concentrating the organic phase, 8 g of the title compound were obtained (m.p.: 64°-66° C.).

1. customAfter termination of the reaction (about 2 h at 25° C.)
2. distillationthe solvent was distilled off under reduced pressure
3. customThe residue thus obtained
4. washThe solution was washed with 5% strength sodium hydroxide solution
5. customAfter drying
6. concentrationconcentrating the organic phase