反应详情

5.13 g (0.03 moles) of 1,2-epoxy-2-(2,4-difluorophenyl)-propane are reacted with 6.35 g (0.045 moles) of 1-(trimethylsilyl)-1,2,4-triazole and 0.14 g (0.0015 moles) of 1,2,4-triazol-1-yl sodium in 40 ml of dimethyl formamide at 80° C. for 3 hours. Then the reaction mixture is cooled to room temperature, neutralized by glacial acetic acid, mixed with 200 ml of water and extracted twice with 50 ml of dichloromethane each. The combined extracts are washed three times with 50 ml of water each, dried over water-free sodium sulfate and evaporated in vacuo. After carrying out a separation as described in Example 5, removal of the solvent and crystallization from n-heptane 6.0 g (64.5%) of the title compound are obtained; m.p.: 51°-53° C.

1. extractionextracted twice with 50 ml of dichloromethane each
2. washThe combined extracts are washed three times with 50 ml of water each,
3. dry with materialdried over water-free sodium sulfate
4. customevaporated in vacuo
5. customa separation
6. customas described in Example 5, removal of the solvent and crystallization from n-heptane 6.0 g (64.5%) of the title compound
7. customare obtained