Hydrazine hydrate (1:1) → HCID 19709709, compound

HRID 725817Notes

Reaction equation

HRID 725817 reaction equation
[CH2:1]([C:5]1[CH:10]=[C:9](Cl)[N:8]2[N:12]=[CH:13][CH:14]=[C:7]2[N:6]=1)[CH2:2][CH2:3][CH3:4].O.[NH2:16][NH2:17]>>[CH2:1]([C:5]1[CH:10]=[C:9]([NH:16][NH2:17])[N:8]2[N:12]=[CH:13][CH:14]=[C:7]2[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 22618004HCID 22618004, compound

Product 1

HCID 19709709HCID 19709709, compound

Procedure

Hydrazine monohydrate (50 ml) was slowly added dropwise to 21.0 g of 5-n-butyl-7-chloropyrazolo[1,5-a]pyrimidine prepared in step (2) of Reference Example 1 at room temperature and stirred at room temperature for 10 hours. After completion of the reaction, the crystals precipitated were collected, washed with water and recrystallized from chloroform-n-hexane to provide 12.6 g of the object compound as colorless crystals (melting point: 126°-129° C.).

Workup

  1. customAfter completion of the reaction
  2. customthe crystals precipitated
  3. customwere collected
  4. washwashed with water
  5. customrecrystallized from chloroform-n-hexane

Sources & evidence

ORD record
ord-c64ccdf8676f4b16b7306419266e9dda
Source dataset
uspto-grants-1998_01
Patent number
US05707997

Reaction notes

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