HCID 15933105, compound → HCID 19709726, compound

HRID 725819Notes

Reaction equation

HRID 725819 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.[CH3:7][CH:8]([C:11](=O)[CH2:12][CH2:13][CH2:14][CH3:15])[C:9]#[N:10]>C1(C)C=CC=CC=1>[NH2:10][C:9]1[N:3]2[N:4]=[CH:5][CH:6]=[C:2]2[N:1]=[C:11]([CH2:12][CH2:13][CH2:14][CH3:15])[C:8]=1[CH3:7]

Participants

4

Reactant 2

HCID 15933105HCID 15933105, compoundHCID 178418806HCID 178418806, compound

Product 1

HCID 19709726HCID 19709726, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
115 °C

Procedure

A toluene solution (2.5 ml) containing 1.8 g of 3-aminopyrazole and 3 g of 2-methyl-3-oxoheptanenitrile was heated at 115° C. for 3.5 hours. Toluene was distilled off under reduced pressure and the residue was recrystallized from ethyl acetate and washed with diethyl ether to provide 2.4 g of the title object compound as colorless crystals.

Workup

  1. distillationToluene was distilled off under reduced pressure
  2. customthe residue was recrystallized from ethyl acetate
  3. washwashed with diethyl ether
  4. customto provide 2.4 g of the title

Sources & evidence

ORD record
ord-988127e807104afe8734c6e4a371fb70
Source dataset
uspto-grants-1998_01
Patent number
US05707997

Reaction notes

Loading…