HCID 19608428, compound → HCID 178422871, compound

HRID 725821Notes

Reaction equation

HRID 725821 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.[CH3:7][C:8]1([CH2:13][CH2:14][C:15](=O)[CH2:16][C:17](OC)=[O:18])[O:12][CH2:11][CH2:10][O:9]1>C1(C)C=CC=CC=1>[OH:18][C:17]1[N:3]2[N:4]=[CH:5][CH:6]=[C:2]2[N:1]=[C:15]([CH2:14][CH2:13][C:8]2([CH3:7])[O:9][CH2:10][CH2:11][O:12]2)[CH:16]=1

Participants

4

Reactant 2

HCID 19608428HCID 19608428, compoundHCID 178418806HCID 178418806, compound

Product 1

HCID 178422871HCID 178422871, compoundYield 84.5%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
115 °C

Procedure

A toluene solution (2 ml) containing 0.90 g of 3-aminopyrazole and 1.90 g of methyl 2-methyl-β-oxo-1,3-dioxolane-2-valerate was refluxed with heating at 115° C. for 1 hour, allowed to cool and then concentrated under reduced pressure. Diethyl ether was added to the residue. The crystals precipitated were collected and washed with diethyl ether to provide 1.85 g of 7-hydroxy-5-[2-(2-methyl-l,3-dioxolane-2-yl)ethyl]pyrazolo[1,5-a]pyrimidine as colorless crystals.

Workup

  1. temperaturewas refluxed
  2. temperatureto cool
  3. concentrationconcentrated under reduced pressure
  4. additionDiethyl ether was added to the residue
  5. customThe crystals precipitated
  6. customwere collected
  7. washwashed with diethyl ether

Sources & evidence

ORD record
ord-7dc029cee830406cae323d6609666f04
Source dataset
uspto-grants-1998_01
Patent number
US05707997

Reaction notes

Loading…