Methanol → HCID 178501119, compound

HRID 725837Notes

Reaction equation

HRID 725837 reaction equation
[NH2:1][CH2:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([OH:11])=[O:10])[CH2:5][CH2:4]1.S(Cl)([Cl:14])=O.[CH3:16]O>>[ClH:14].[NH2:1][CH2:2][C@H:3]1[CH2:4][CH2:5][C@H:6]([C:9]([O:11][CH3:16])=[O:10])[CH2:7][CH2:8]1

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 178511262HCID 178511262, compound

Product 1

HCID 178501119HCID 178501119, compound

Procedure

103 g of trans-4-aminomethyl-cyclohexanecarboxylic acid are dissolved in 1 l of methanol and 48 ml of thionylchloride are added dropwise thereto whilst cooling with ice. After 2 hours at ambient temperature the solvent is distilled off using a rotary evaporator, the residue is stirred with 300 ml of tert.-butylmethylether, suction filtered and dried.

Workup

  1. temperaturewhilst cooling with ice
  2. distillationAfter 2 hours at ambient temperature the solvent is distilled off
  3. customa rotary evaporator
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-5b095b33ab334bd2886fec7f64e368d9
Source dataset
uspto-grants-1998_01
Patent number
US05707989

Reaction notes

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