Cyclohexylamine → HCID 15295216, compound

HRID 725838Notes

Reaction equation

HRID 725838 reaction equation
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]2[C:17]3[N:25]=[C:24](S(C)=O)[N:23]=[CH:22][C:18]=3[N:19]=[CH:20][N:21]=2)[CH:12]=[CH:13][CH:14]=1.CC1C=C(NC2C3N=C(S(C)(=O)=O)N=CC=3N=CN=2)C=CC=1>O1CCOCC1>[CH3:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]2[C:17]3[N:25]=[C:24]([NH:7][CH:1]4[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]4)[N:23]=[CH:22][C:18]=3[N:19]=[CH:20][N:21]=2)[CH:12]=[CH:13][CH:14]=1

Participants

5

Reactant 3

HCID 7965CyclohexylamineHCID 15341441HCID 15341441, compoundHCID 15341442HCID 15341442, compound

Product 1

HCID 15295216HCID 15295216, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1.3 ml of cyclohexylamine are added to 0.4 g of a mixture of 4-[(3-methylphenyl)amino]-6-methylsulphinyl-pyrimido[5,4-d]pyrimidine and 4-[(3-methylphenyl)amino]-6-methylsulphonylpyrimido[5,4-d]pyrimidine in 10 ml of dioxane and the mixture is stirred at room temperature overnight. The reaction mixture is evaporated, water is added to the residue and the solid is filtered off with suction. The crude product is purified by chromatography over a silica gel column with petroleum ether/ethyl acetate (2:1).

Workup

  1. customThe reaction mixture is evaporated
  2. additionwater is added to the residue
  3. filtrationthe solid is filtered off with suction
  4. customThe crude product is purified by chromatography over a silica gel column with petroleum ether/ethyl acetate (2:1)

Sources & evidence

ORD record
ord-3ec5e7dbeecc434f89b6b7106253b979
Source dataset
uspto-grants-1998_01
Patent number
US05707989

Reaction notes

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