Methanol → HCID 86751908, compound

HRID 725858Notes

Reaction equation

HRID 725858 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:36])[NH:10][CH2:11][C:12]([N:14]2[CH:18]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:17]([C:25]([O:27]C)=[O:26])[CH2:16][CH:15]2[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[O:13])=[CH:4][CH:3]=1.O.CO>[OH-].[K+]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:36])[NH:10][CH2:11][C:12]([N:14]2[CH:18]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:17]([C:25]([OH:27])=[O:26])[CH2:16][CH:15]2[C:29]([O:31][C:32]([CH3:34])([CH3:33])[CH3:35])=[O:30])=[O:13])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 962WaterHCID 86751909HCID 86751909, compound

Product 1

HCID 86751908HCID 86751908, compoundYield 68.5%

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

A The reaction is carried out in a way analogous to that described in Example 3, but from 2.1 g of 2-tert-butyl 4-methyl (2RS,4RS,5SR)-1-{2-[3-(4-chlorophenyl)ureido]acetyl}-5-phenylpyrrolidine-2,4-dicarboxylate in a mixture of 4 cm3 of a normal aqueous potassium hydroxide solution, 20 cm3 of distilled water and 60 cm3 of methanol. After treatment, there are obtained 1.4 g of 2-tert-butyl hydrogen (2RS,4SR,5SR)-1-{2-[3-(4-chlorophenyl)ureido]acetyl}-5-phenylpyrrolidine-2,4-dicarboxylate, melting at 248° C.

Sources & evidence

ORD record
ord-4b7a0cbc37954e30ae045eaa5ed22374
Source dataset
uspto-grants-1998_01
Patent number
US05707991

Reaction notes

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