Methanol → 2-tert-butyl hydrogen (2RS,4SR,5SR)-1-{2-[3-(4-chlorophenyl)ureido]acetyl}-5-phenylpyrrolidine-2,4-dicarboxylate

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Reaction Steps

A The reaction is carried out in a way analogous to that described in Example 3, but from 2.1 g of 2-tert-butyl 4-methyl (2RS,4RS,5SR)-1-{2-[3-(4-chlorophenyl)ureido]acetyl}-5-phenylpyrrolidine-2,4-dicarboxylate in a mixture of 4 cm3 of a normal aqueous potassium hydroxide solution, 20 cm3 of distilled water and 60 cm3 of methanol. After treatment, there are obtained 1.4 g of 2-tert-butyl hydrogen (2RS,4SR,5SR)-1-{2-[3-(4-chlorophenyl)ureido]acetyl}-5-phenylpyrrolidine-2,4-dicarboxylate, melting at 248° C.

Provenance & Evidence