Potassium Hydroxide → HCID 86751917, compound

HRID 725863Notes

Reaction equation

HRID 725863 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[C:7]([NH:11][C:12](=[O:45])[NH:13][CH2:14][C:15]([N:17]2[CH:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH:20]([CH3:28])[CH2:19][C:18]2([C:36](=[O:44])[NH:37][C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[O:16])[CH:8]=[CH:9][CH:10]=1)=[O:4].[OH-].[K+]>O.CO>[C:32]([O:31][C:29]([C:18]1([C:36](=[O:44])[NH:37][C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[CH2:19][CH:20]([CH3:28])[CH:21]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[N:17]1[C:15](=[O:16])[CH2:14][NH:13][C:12](=[O:45])[NH:11][C:7]1[CH:6]=[C:5]([CH:10]=[CH:9][CH:8]=1)[C:3]([OH:4])=[O:2])=[O:30])([CH3:33])([CH3:34])[CH3:35]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 86751918HCID 86751918, compound

Product 1

HCID 86751917HCID 86751917, compoundYield 31.3%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A The reaction is carried out in a way analogous to that described in Example 3, but from 3.6 g of tert-butyl (2RS,4RS,5SR)-1-{2-[3-(3-(methoxycarbonyl)phenyl)ureido]acetyl}-4-methylphenylcarbamoyl-5-phenylpyrrolidine-2-carboxylate and 0.33 g of potassium hydroxide in a mixture of 20 cm3 of distilled water and 60 cm3 of methanol. After treatment, there are obtained 1.1 g of (2RS,4RS,5SR)-3-{3-[2-(2-tert-butoxycarbonyl-5-phenyl-4-methylphenylcarbamoyl-1-pyrrolidinyl)-2-oxoethyl]ureido}benzoic acid, melting at 238° C.

Sources & evidence

ORD record
ord-1f247933561b4c1cbd23f10ce91e003d
Source dataset
uspto-grants-1998_01
Patent number
US05707991

Reaction notes

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